In some cases, patients report temporary improvements in mood while taking tramadol, especially those with underlying depression. This is partly due to the increased levels of serotonin and norepinephrine in the brain, which are the same neurotransmitters targeted by many antidepressants. In fact, early studies suggested tramadol might possess antidepressant-like properties, prompting interest in its potential use beyond pain relief. Some people taking tramadol for pain even report elevated mood, reduced anxiety, and increased energy, especially in the short term.